Virginia will be without its top defensive lineman and defensive back when it hosts Duke at 3:30 p.m., Saturday.
Both defensive tackle Brent Urban (lower extremity) and cornerback Demetrious Nicholson (toe) will not play against the Blue Devils, according to an injury report released by UVa on Thursday afternoon.
Among defensive linemen, Urban leads the nation in passes defended with eight. The 6-foot-7, 295-pound senior, along with defensive end Eli Harold, leads the Cavs in tackles for loss with 7.5. He left last week's 27-26 loss to Maryland early in the second quarter.
"He’s our best defensive player," defensive end Jake Snyder said after the Terrapin game. "That’s the only way to really put it. He’s been a force this year. No one’s been able to stop him. He’s a guy that everyone can really around. It hurt to see him go down."
To replace Urban, UVa has options. It can slide Snyder over to defensive tackle and bring in Mike Moore or Trent Corney to play end. It can also slot in freshman Donte Wilkins at tackle.
Nicholson will miss his second consecutive game after having to be helped off the field by quarterback David Watford following a 48-27 loss to Ball State on Oct. 5.
Nicholson, a three-year starter, has 20 tackles and one interception this season. Freshman Tim Harris was the extra CB added last week at Maryland with Nicholson out. Harris made five tackles, including one for loss.
However, the Wahoos were torched for 332 passing yards by Terrapins' backup QB Caleb Rowe.
Placekicker Ian Frye will miss his third straight game with a hip flexor, meaning double-duty again for punter Alec Vozenilek.
Virginia probables to play are linebacker Daquan Romero (upper extremity) and running back Khalek Shepherd (trunk).
Both Urban (second team) and Nicholson (second team) are among six Cavaliers to make Phil Steele's midseason All-ACC teams.